Pharm Ingredients
Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder
Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder Manufacturers
As a specialist in plant extracts, Kintainutri® Extract Company is dedicated to producing a high-quality series of szechuan lovage root extract (tetramethylpyrazine) powder.Its flagship products include high-purity 98% Tetramethylpyrazine and Ligustrazine Hydrochloride, which provide global clients with safe, pure, and highly effective raw materials.
Tetramethylpyrazine is an active ingredient extracted from the traditional Chinese medicinal herb Chuanxiong. Widely used clinically as an anti-platelet agent, it effectively dilates blood vessels, inhibits platelet aggregation, and improves microcirculation, thereby significantly increasing blood flow to the coronary arteries and the brain. Based on these pharmacological properties, Ligustrazine is extensively used in the prevention and treatment of cardiovascular and cerebrovascular diseases, ischemic stroke, cancer, and diabetes.
| Product Name | Source | Active Ingredients | Best-selling Specifications |
|---|---|---|---|
| Ligusticum Chuanxiong Extract Powder | Ligusticum Rhizome | Ligustrazine/Tetramethylpyrazine | 98% |
| Ligustrazine Hydrochloride | 98% | ||
| ITEM | STANDARD | TEST METHOD |
|---|---|---|
| Physical & Chemical | ||
| Oleanolic acid | ≥98% | HPLC |
| Appearance | White Crystalline Powder | Visual |
| Odor | Characteristic | Organoleptic |
| Particle Size | 95% pass 80 mesh | USP<786> |
| Loss on Drying | ≤5.0% | USP<731> |
| Ash | ≤5.0% | USP<281> |
| Heavy Metal | ||
| Pb | ≤3.0ppm | ICP-MS |
| As | ≤2.0ppm | ICP-MS |
| Cd | ≤1.0ppm | ICP-MS |
| Hg | ≤0.5ppm | ICP-MS |
| Microbiological Test | ||
| Total Plate Count | ≤1,000cfu/g | AOAC |
| Yeast and Mold | ≤100cfu/g | AOAC |
| E.Coli | ≤0.4MPN/g | AOAC |
| Salmonella | Negative | AOAC |
| staphylococcus aureus | Negative | AOAC |
How To Make Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder?
Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder Benefits
Tetramethylpyrazine: Cardiovascular Benefits
Tetramethylpyrazine exerts cardiovascular protective effects through multiple pathways: first, acting as a natural calcium antagonist, it inhibits calcium ion influx, thereby dilating blood vessels and reducing peripheral resistance; second, it activates the nitric oxide pathway, promoting eNOS phosphorylation and increasing NO production to improve vascular endothelial function; third, it inhibits the abnormal proliferation and migration of vascular smooth muscle cells, thereby delaying vascular remodeling; and fourth, it mitigates myocardial and vascular endothelial injury by scavenging reactive oxygen species and inhibiting apoptosis and inflammatory responses.
Additionally, szechuan lovage root extract (tetramethylpyrazine) powder exhibits distinct anti-platelet aggregation activity, helping to prevent thrombosis. These properties make it valuable as an adjunct therapy for cardiovascular conditions such as hypertension, coronary heart disease, and heart failure, and render it suitable for use as a functional ingredient in the development of dietary supplements or pharmaceutical products.
Tetramethylpyrazine: Renoprotective Effects
Szechuan lovage root extract (tetramethylpyrazine) powder exerts renoprotective effects through multiple mechanisms: first, it combats oxidative stress by activating the Nrf2 pathway, reducing reactive oxygen species (ROS) production, and mitigating damage to renal tubular epithelial cells; second, it inhibits inflammatory responses by blocking the NF-κB pathway and lowering levels of inflammatory cytokines such as TNF-α and IL-6; third, it prevents apoptosis by regulating the Bax/Bcl-2 balance and inhibiting Caspase activation; and fourth, it modulates autophagy to clear damaged mitochondria.
Preclinical studies have demonstrated that tetramethylpyrazine effectively prevents contrast-induced nephropathy, ischemia-reperfusion injury, and drug-induced acute kidney injury (e.g., caused by cisplatin or gentamicin), while also delaying the progression of renal fibrosis and chronic kidney disease. These properties have made it a focal point for the development of functional ingredients with renoprotective capabilities.
Ligustrazine Hydrochloride: Anti-Aging & Repair
Ligustrazine hydrochloride exhibits potent antioxidant activity; it effectively scavenges DPPH radicals and hydrogen peroxide, inhibits the formation of malondialdehyde (a product of lipid peroxidation), and mitigates damage to skin cells caused by reactive oxygen species. When formulated as a liposome-hydrogel transdermal delivery system, it enhances skin adhesion and drug permeability, boosts superoxide dismutase (SOD) activity, and significantly alleviates symptoms of UV-induced photoaging, including erythema, wrinkles, skin roughness, and ulceration.
Furthermore, ligustrazine hydrochloride inhibits the secretion of inflammatory cytokines and tyrosinase activity, thereby reducing melanin production. These properties position it as a promising candidate for development in functional skincare, anti-photoaging repair, and skin-brightening products.
What Is Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder Used For？
Pharmaceutical sector
Szechuan lovage root extract (tetramethylpyrazine) powder is primarily used clinically as an adjunctive therapy for cardiovascular and cerebrovascular diseases. Its key applications include treating ischemic stroke (improving cerebral circulation and protecting neurological function), coronary heart disease and angina (dilating coronary arteries and increasing myocardial blood supply), and hypertension-related complications (such as diabetic nephropathy).
Additionally, it is used to alleviate pulmonary heart disease, pulmonary hypertension, and vasospastic disorders. Its mechanisms of action involve inhibiting platelet aggregation, vasodilation, and providing anti-oxidative and anti-inflammatory effects. It is well-suited for development as an adjunctive therapeutic agent in oral or injectable formulations.
Tetramethylpyrazine supplement
As a dietary supplement, tetramethylpyrazine is primarily used for cardiovascular and cerebrovascular health. By dilating blood vessels, inhibiting platelet aggregation, and improving microcirculation, it helps maintain cardiovascular health and cerebral blood supply. Furthermore, it has traditional applications in menstrual health, helping to alleviate discomfort caused by blood stasis. Its antioxidant properties also help relieve physical fatigue and boost vitality. Selecting high-purity Ligusticum chuanxiong extract is crucial for developing effective functional dietary supplements.
Cosmetic Applications
Ligustrazine Hydrochloride holds broad application prospects in the cosmetics industry, particularly for anti-aging, skin-brightening, and soothing products. Its primary mechanism involves improving skin microcirculation; by dilating capillaries and promoting blood flow, it delivers more oxygen and nutrients to skin cells, thereby brightening the complexion and reducing dullness. Additionally, its potent antioxidant activity enables it to scavenge free radicals, inhibit melanin production, delay photoaging, and reduce UV-induced erythema and wrinkles.
Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder Side Effects And Safety
Adverse reactions reported to date have been associated exclusively with tetramethylpyrazine injections and include phlebitis, chills, fever, rash, pruritus, chest tightness, palpitations, dizziness, dyspnea, and sore throat. No adverse events related to oral tetramethylpyrazine therapy have been reported so far. Clinical observations at the researchers' institution also confirm that oral szechuan lovage root extract (tetramethylpyrazine) powder is safe and free of significant adverse reactions. Therefore, based on current evidence, oral tetramethylpyrazine demonstrates a favorable safety profile and is a suitable candidate for development as a long-term medication.
Where Can I Buy Szechuan Lovage Root Extract (Tetramethylpyrazine) Powder?
Kintainutri® specializes in the R&D and production of high-purity szechuan lovage root extract (tetramethylpyrazine) powder. We manufacture Tetramethylpyrazine (TMP) powder and Ligustrazine Hydrochloride powder at 98% purity adhere to rigorous standards at every stage, from raw material selection to finished product testing.
Kintainutri® is a trusted supply chain partner. Whether for applications supporting cardiovascular and cerebrovascular health, renal protection, or anti-photoaging skincare, we are committed to providing stable, safe, and traceable botanical ingredients. Please contact us for bulk purchasing inquiries. Free samples are available!
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
FAQ
-
What is the benefit of ligusticum Chuanxiong extract powder?
Chuanxiong extract powder (with ligustrazine as its primary active ingredient) offers significant cardioprotective and cerebrovascular-protective effects. It enhances coronary and cerebral blood flow by dilating blood vessels, inhibiting platelet aggregation, and improving microcirculation, thereby aiding in the prevention and management of coronary heart disease, angina, and ischemic stroke. Additionally, it provides multiple benefits—including antioxidant and anti-inflammatory properties, renal protection, relief from menstrual discomfort, anti-fatigue effects, and improved skin microcirculation—making it a versatile natural plant extract suitable for use in dietary supplements, functional foods, and cosmetics.
About Us
